1.
Chem Commun (Camb)
; 52(3): 549-52, 2016 Jan 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26538152
RESUMO
Repurposing the "protein-labeling toolkit" for RNA research could be a pragmatic approach for developing new RNA-labeling methods. We have evolved an RNA aptamer that tightly binds benzylguanine (bG), the key ligand for the protein SNAP-tag. The aptamer tightly binds bG fluorophores and can be purified from cellular RNA with bG agarose under native conditions.